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Sophie Lucas - Targeting GARP on Tregs: a novel approach for cancer immunotherapy ?

  • Date de parution : 14/05/2018
  • Durée : 36 min
  • Crédits :

Résumé de la vidéo

Regulatory T lymphocytes (Tregs) are essential to prevent auto-immunity, but excessive Treg function contributes to cancer progression by inhibiting anti-tumor immune responses. Tregs exert contact-dependent inhibition of immune cells through the production of active TGF-β1. On the Treg cell surface, TGF-β1 is in an inactive form bound to membrane protein GARP and then activated by an unknown mechanism. We demonstrate that GARP is involved in this activa...

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