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Pierre Milpied - Class-switched memory B cells remodel BCRs within secondary germinal centers

  • Date de parution : 14/05/2018
  • Durée : 35 min
  • Crédits :

Résumé de la vidéo

High affinity antibody responses to pathogens and vaccines require affinity maturation of antigen-specific B cells in germinal centers (GC). In GCs, B cells coordinate diverse functional programs which must be carefully orchestrated to ensure B cell receptor (BCR) diversification and selection, while avoiding off-target mutational activity and lymphomagenesis. In my talk, I will show how we have used integrative single-cell analyses of gene expression, phe...

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