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Patricia Amé-Thomas - T follicular helper cells in follicular lymphoma : one of the most important players in the malignant B cell niche

  • Date de parution : 12/05/2016
  • Durée : 23 min
  • Crédits :

Résumé de la vidéo

Follicular lymphoma (FL) is the most frequent indolent lymphoma and results from the malignant transformation of germinal centre B cells in secondary lymphoid organs. Beside the genetic alterations associated with the deregulation of the anti-apoptotic protein Bcl2, the growth of malignant FL B cells relies on the development of a supportive microenvironment, which forms a specialized cell niche contributing to disease development, progression, and drug re...

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