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Marco Frentsch - CD8+ T cell-derived CD40L mediates cytotoxicity against cancer cells

  • Date de parution : 14/05/2018
  • Durée : 26 min
  • Crédits :

Résumé de la vidéo

Exploiting T-cell therapy is emerging as one of the most effective treatment options to combat malignancies. However, which subset and functional quality of CD8+ T cells is more suitable for achieving effective and durable responses in the strong immunosuppressive context of cancer is still a matter of debate and investigation. We detected recently that in average 25% of human memory CD8+ T cells express CD40L, a strong immunostimulatory molecule of activa...

Sophie Lucas - Targeting GARP on Tregs: a novel approach for cancer immunotherapy ?

  • Date de parution : 14/05/2018
  • Durée : 36 min
  • Crédits :

Résumé de la vidéo

Regulatory T lymphocytes (Tregs) are essential to prevent auto-immunity, but excessive Treg function contributes to cancer progression by inhibiting anti-tumor immune responses. Tregs exert contact-dependent inhibition of immune cells through the production of active TGF-β1. On the Treg cell surface, TGF-β1 is in an inactive form bound to membrane protein GARP and then activated by an unknown mechanism. We demonstrate that GARP is involved in this activa...

Eliane Piaggio - IL-2-based therapies for the treatment of autoimmunity and cancer

  • Date de parution : 14/05/2018
  • Durée : 37 min
  • Crédits :

Résumé de la vidéo

Interleukine-2 (IL-2) is a cytokine with both immune stimulating and suppressive function. Consequently, it has been used in the clinic at high doses to stimulate the immune response against cancer and more recently it is being evaluated at low doses to block the immune response in conditions of undesired immune activation, such as autoimmunity or during GVHD. However, IL-2 can be toxic, and depending on the desired effect, IL-2 action needs to be re-direc...

Pierre Milpied - Class-switched memory B cells remodel BCRs within secondary germinal centers

  • Date de parution : 14/05/2018
  • Durée : 35 min
  • Crédits :

Résumé de la vidéo

High affinity antibody responses to pathogens and vaccines require affinity maturation of antigen-specific B cells in germinal centers (GC). In GCs, B cells coordinate diverse functional programs which must be carefully orchestrated to ensure B cell receptor (BCR) diversification and selection, while avoiding off-target mutational activity and lymphomagenesis. In my talk, I will show how we have used integrative single-cell analyses of gene expression, phe...

Sian Henson - mTOR-independent regulation of senescent human CD8+ T cells

  • Date de parution : 12/05/2016
  • Durée : 23 min
  • Crédits :

Résumé de la vidéo

Ageing is accompanied by alterations to T cell immunity and also by a low-grade chronic inflammatory state termed inflammageing. The significance of these phenomena is highlighted by baseline inflammation being a predictor of earlier mortality. As T cells age they lose proliferative capacity but they secrete high levels of pro-inflammatory cytokines and show potent cytotoxic activity. The maintenance of an inflammatory state is an energy-intensive process ...

Danilo Norata - Translating adaptive immune cell metabolism : a lesson from inherited and acquired dyslipidemias

  • Date de parution : 12/05/2016
  • Durée : 30 min
  • Crédits :

Résumé de la vidéo

The immune response requires major changes to metabolic processes, including lipid metabolism and indeed, energy metabolism and functional activation are fully integrated in immune cells. Immune cell lipid metabolism has therefore become an attractive target area for therapeutic purposes. The importance of understanding and manipulating the integration of systemic and immune cell lipid metabolism through in-depth analysis of immune cell phenotype and funct...

Bernard Vanhove - Development of CD28 antagonists to differentially impact effector versus regulatory cells post transplantation

  • Date de parution : 12/05/2016
  • Durée : 27 min
  • Crédits :

Résumé de la vidéo

"CD28 blockade" has been long referred to as use of CTLA4-Ig. However it has now been recognized that CTLA4-Ig, which actually binds CD80/86, inhibits CD28-mediated costimulation as well as CTLA-4 and PDL-1 co-inhibitory signals that are important immune checkpoints also involved in the control of Treg suppression. The development of non-agonist monovalent anti-CD28 antibodies made it possible to study the biological and therapeutic impacts of &q...

Xingxing Zang - HHLA2 and TMIGD2: the newest members of the B7 and CD28 families

  • Date de parution : 12/05/2016
  • Durée : 28 min
  • Crédits :

Résumé de la vidéo

CTLA-4 and the PD-1/PD-L1 pathway are current focuses for cancer immunotherapy. This presentation will discuss other new immune checkpoints for human cancer immunotherapy, including HHLA2/TMIGD2, B7x, and B7-H3.

Thomas Gajewski - Targeting regulatory pathways in the tumor microenvironment for cancer immunotherapy

  • Date de parution : 12/05/2016
  • Durée : 34 min
  • Crédits :

Résumé de la vidéo

Dr. Thomas Gajewski carries out translational research with a focus on cancer immunology. He directs the Melanoma Oncology clinic, is Leader of the Immunology and Cancer Program, and oversees the Human Immunologic Monitoring (HIM)/cGMP Core Facility of the Comprehensive Cancer Center at the University of Chicago. His work focuses on understanding fundamental aspects of immune regulation, applying this knowledge towards studies of anti-tumor immunity, and c...

Adrian Hayday - Gamma Delta T cells: conserved cells with essential functions

  • Date de parution : 12/05/2016
  • Durée : 36 min
  • Crédits :

Résumé de la vidéo

Some extraordinary clinical successes of immunotherapy have had game-changing effects on the way we view the interaction of the immune system with our tissues. In that regard, we have focussed on the fact that many murine, “non-lymphoid” tissues, such as the skin, gut and reproductive tissue are commonly rich in tissue-resident  T cells. We have shown that such cells make rapid innate-like responses to molecular markers of tissue perturbation, r...

Paolo Dellabona - iNKT cells control tumor progression via differential modulation

  • Date de parution : 12/05/2016
  • Durée : 27 min
  • Crédits :

Résumé de la vidéo

Cancer immunosurveillance involves a complex interplay between malignant cells and the tumor microenvironment, composed of infiltrating immune cells and tumor-supporting stromal cells. Unraveling these interactions will help increasing our understanding of oncogenesis and may provide new targets for better therapies. We have discovered that iNKT cells control the progression of mouse prostate cancer by differentially modulating tumor-associated macrophages...

Patricia Amé-Thomas - T follicular helper cells in follicular lymphoma : one of the most important players in the malignant B cell niche

  • Date de parution : 12/05/2016
  • Durée : 23 min
  • Crédits :

Résumé de la vidéo

Follicular lymphoma (FL) is the most frequent indolent lymphoma and results from the malignant transformation of germinal centre B cells in secondary lymphoid organs. Beside the genetic alterations associated with the deregulation of the anti-apoptotic protein Bcl2, the growth of malignant FL B cells relies on the development of a supportive microenvironment, which forms a specialized cell niche contributing to disease development, progression, and drug re...

Carla Baan - Follicular T helper cells and humoral reactivity in kidney transplant patients

  • Date de parution : 12/05/2016
  • Durée : 19 min
  • Crédits :

Résumé de la vidéo

Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30–50% of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a specialized T-cell subset has been identified—T follicular helper (Tfh) cells—which support activated B cells via interleukin (IL)-21 after binding to the I...

Nathalie Schmitt - Pathways promoting the differentiation of T follicular helper cells in humans

  • Date de parution : 12/05/2016
  • Durée : 24 min
  • Crédits :

Résumé de la vidéo

T follicular helper (Tfh) cells are a subset of CD4 T cell specialized in providing help to B cells. Tfh cell response needs to be regulated because a too strong Tfh response can lead to autoimmunity while a too weak Tfh response leads to insufficient antibody response to pathogens. Therefore, elucidating the pathways associated with Tfh cell differentiation is of prime importance to understand how Tfh cell responses are regulated in vivo. Our research has...

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