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Marco Frentsch - CD8+ T cell-derived CD40L mediates cytotoxicity against cancer cells

  • Date de parution : 14/05/2018
  • Durée : 26 min
  • Crédits :

Résumé de la vidéo

Exploiting T-cell therapy is emerging as one of the most effective treatment options to combat malignancies. However, which subset and functional quality of CD8+ T cells is more suitable for achieving effective and durable responses in the strong immunosuppressive context of cancer is still a matter of debate and investigation. We detected recently that in average 25% of human memory CD8+ T cells express CD40L, a strong immunostimulatory molecule of activa...

Sophie Lucas - Targeting GARP on Tregs: a novel approach for cancer immunotherapy ?

  • Date de parution : 14/05/2018
  • Durée : 36 min
  • Crédits :

Résumé de la vidéo

Regulatory T lymphocytes (Tregs) are essential to prevent auto-immunity, but excessive Treg function contributes to cancer progression by inhibiting anti-tumor immune responses. Tregs exert contact-dependent inhibition of immune cells through the production of active TGF-β1. On the Treg cell surface, TGF-β1 is in an inactive form bound to membrane protein GARP and then activated by an unknown mechanism. We demonstrate that GARP is involved in this activa...

Eliane Piaggio - IL-2-based therapies for the treatment of autoimmunity and cancer

  • Date de parution : 14/05/2018
  • Durée : 37 min
  • Crédits :

Résumé de la vidéo

Interleukine-2 (IL-2) is a cytokine with both immune stimulating and suppressive function. Consequently, it has been used in the clinic at high doses to stimulate the immune response against cancer and more recently it is being evaluated at low doses to block the immune response in conditions of undesired immune activation, such as autoimmunity or during GVHD. However, IL-2 can be toxic, and depending on the desired effect, IL-2 action needs to be re-direc...

Pierre Milpied - Class-switched memory B cells remodel BCRs within secondary germinal centers

  • Date de parution : 14/05/2018
  • Durée : 35 min
  • Crédits :

Résumé de la vidéo

High affinity antibody responses to pathogens and vaccines require affinity maturation of antigen-specific B cells in germinal centers (GC). In GCs, B cells coordinate diverse functional programs which must be carefully orchestrated to ensure B cell receptor (BCR) diversification and selection, while avoiding off-target mutational activity and lymphomagenesis. In my talk, I will show how we have used integrative single-cell analyses of gene expression, phe...

Mélanome : les promesses de l'immunothérapie

  • Date de parution : 02/11/2015
  • Durée : 11 min
  • Crédits : Julie Danet

Résumé de la vidéo

Et si notre corps et nos propres cellules pouvaient nous aider à lutter contre le cancer ? C’est ce que propose aujourd’hui l’immunothérapie. Une équipe de recherche nantaise du Centre de Recherche en Cancérologie Nantes-Angers (CRCNA) étudie actuellement les différents acteurs du système immunitaire pour mettre en place de nouveaux traitements des cancers comme le mélanome.

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