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Sian Henson - mTOR-independent regulation of senescent human CD8+ T cells

  • Date de parution : 12/05/2016
  • Durée : 23 min
  • Crédits :

Résumé de la vidéo

Ageing is accompanied by alterations to T cell immunity and also by a low-grade chronic inflammatory state termed inflammageing. The significance of these phenomena is highlighted by baseline inflammation being a predictor of earlier mortality. As T cells age they lose proliferative capacity but they secrete high levels of pro-inflammatory cytokines and show potent cytotoxic activity. The maintenance of an inflammatory state is an energy-intensive process ...

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