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Carla Baan - Follicular T helper cells and humoral reactivity in kidney transplant patients

  • Date de parution : 12/05/2016
  • Durée : 19 min
  • Crédits :

Résumé de la vidéo

Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30–50% of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a specialized T-cell subset has been identified—T follicular helper (Tfh) cells—which support activated B cells via interleukin (IL)-21 after binding to the I...

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