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Bernard Vanhove - Development of CD28 antagonists to differentially impact effector versus regulatory cells post transplantation

  • Date de parution : 12/05/2016
  • Durée : 27 min
  • Crédits :

Résumé de la vidéo

"CD28 blockade" has been long referred to as use of CTLA4-Ig. However it has now been recognized that CTLA4-Ig, which actually binds CD80/86, inhibits CD28-mediated costimulation as well as CTLA-4 and PDL-1 co-inhibitory signals that are important immune checkpoints also involved in the control of Treg suppression. The development of non-agonist monovalent anti-CD28 antibodies made it possible to study the biological and therapeutic impacts of &q...

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